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Binding and Kinetic Mechanisms of the Zeta Class Glutathione Transferase

Ricci, G; Turella, Paola; De Maria, Francesca; Antonini, Giovanni; Nardocci, Luisa; Board, Philip; Parker, Michael William; Carbonelli, Maria; Frederici, Giorgio; Caccuri, Anna Maria


The Zeta class of glutathione transferases (GSTs) has only recently been discovered and hence has been poorly characterized. Here we investigate the substrate binding and kinetic mechanisms of the human Zeta class GSTZ1c-1c by means of pre-steady state and steady-state experiments and site-directed mutagenesis. Binding of GSH occurs at a very low rate compared with that observed for the more recently evolved GSTs (Alpha, Mu, and Pi classes). Moreover, the single step binding mechanism observed...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M404631200


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