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Topological Analysis of Glucosyltransferase GtrV of Shigella flexneri by a Dual Reporter System and Indentification of a Unique Reentrant Loop

Korres, Haralambos; Verma, Naresh


Lipopolysaccharide, particularly the O-antigen component, is one of many virulence determinants necessary for Shigella flexneri pathogenesis. O-Antigen modification is mediated by glucosyltransferase genes (gtr) encoded by temperate serotype-converting bacteriophages. The gtrV gene encodes the GtrV glucosyltransferase, an integral membrane protein that catalyzes the transfer of a glucosyl residue via an α1,3 linkage to rhamnose II of the O-antigen unit. This mediates conversion of S. flexneri...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M401316200


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