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Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays

Tierney, Mary (Louise); Osborn, Kate; Milburn, Peter J; Stowell, M; Howitt, Susan


Intact acetylcholine receptors have been purified on a novel affinity resin from three electric fish endemic to Australian waters. Their binding properties and morphology are compared with those of their northern hemisphere homolog, Torpedo marmorata. All four exhibit apparent dissociation constants, K d, in the nanomolar range for the snake neurotoxin α-bungarotoxin and have a distinctive rosette-like appearance when viewed in negative stain under the electron microscope. Furthermore, these...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Experimental Biology
DOI: 10.1242/jeb.01204


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