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Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis

Kumar, Rakesh K; Herbert, John; Foster, Paul S


Background: Growth factors produced by airway epithelial cells may be important in the pathogenesis of subepithelial fibrosis, a distinctive lesion of chronic human asthma. Objective: To examine the relationship between the development of subepithelial fibrosis and the expression of transforming growth factor-β1 (TGF-β1) and ligands for the epidermal growth factor receptor. Methods: BALB/c mice sensitized to ovalbumin were chronically challenged by inhalation of low levels of antigen, leading...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Clinical and Experimental Allergy
DOI: 10.1111/j.1365-2222.2004.1917.x


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