Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis
Background: Growth factors produced by airway epithelial cells may be important in the pathogenesis of subepithelial fibrosis, a distinctive lesion of chronic human asthma. Objective: To examine the relationship between the development of subepithelial fibrosis and the expression of transforming growth factor-β1 (TGF-β1) and ligands for the epidermal growth factor receptor. Methods: BALB/c mice sensitized to ovalbumin were chronically challenged by inhalation of low levels of antigen, leading...[Show more]
|Collections||ANU Research Publications|
|Source:||Clinical and Experimental Allergy|
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