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Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-Mig, CXCL9)

Fulkerson, Patricia; Zimmermann, Nives; Brandt, Eric; Muntel, Emily; Doepker, Matthew; Kavanaugh, Jessica; Mishra, Anil; Witte, David; Zhang, Hong-Wei; Farber, Joshua; Yang, Ming; Foster, Paul S; Rothenberg, Marc E

Description

Experimental analysis of allergic airway inflammation (AAI) in animals and humans is associated with coordinate gene induction. Using DNA microarray analysis, we have identified a large panel of AAI signature genes. Unexpectedly, the allergen-challenged lung (a T helper 2 microenvironment) was found to be associated with the expression of T helper 1-associated CXCR3 ligands, monokine induced by IFN-γ (Mig), and IFN-γ-inducible protein of 10 kDa (IP-10). Here we report that Mig functions as a...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86289
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0308544100

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