Kumar, Rakesh K; Herbert, John; Webb, Dianne; Li, Lily; Foster, Paul S
The relative contribution of Th2 and Th1 cytokines to the pathogenesis of lesions of chronic asthma remains poorly understood. To date, therapeutic inhibition of Th2 cytokines has proved disappointing. We used a clinically relevant model of chronic allergic asthma in mice to compare the effects of administering neutralizing antibodies to interleukin (IL)-13, IL-5, and interferon-γ (IFN-γ) to animals with established disease. As has been observed in clinical studies, anti-IL-5 inhibited both...[Show more]
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