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Chemokines in Eosinophil-associated Gastrointestinal Disorders

Hogan, Simon; Rothenberg, Marc; Forbes, Elizabeth; Prescott, Vanessa; Matthaei, Klaus; Foster, Paul S

Description

Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical...[Show more]

dc.contributor.authorHogan, Simon
dc.contributor.authorRothenberg, Marc
dc.contributor.authorForbes, Elizabeth
dc.contributor.authorPrescott, Vanessa
dc.contributor.authorMatthaei, Klaus
dc.contributor.authorFoster, Paul S
dc.date.accessioned2015-12-13T23:07:36Z
dc.identifier.issn1529-7322
dc.identifier.urihttp://hdl.handle.net/1885/86279
dc.description.abstractEosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
dc.publisherCurrent Science Inc
dc.sourceCurrent allergy and Asthma Reports
dc.subjectKeywords: alpha chemokine; beta chemokine; CD4 antigen; chemokine; chemokine receptor CCR1; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CCR4; chemokine receptor CCR5; chemokine receptor CCR6; chemokine receptor CCR7; chemokine receptor CCR8
dc.titleChemokines in Eosinophil-associated Gastrointestinal Disorders
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume4
dc.date.issued2004
local.identifier.absfor110701 - Allergy
local.identifier.ariespublicationMigratedxPub15104
local.type.statusPublished Version
local.contributor.affiliationHogan, Simon, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRothenberg, Marc, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationForbes, Elizabeth, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPrescott, Vanessa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMatthaei, Klaus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage74
local.bibliographicCitation.lastpage82
dc.date.updated2015-12-12T08:09:54Z
local.identifier.scopusID2-s2.0-2142699479
CollectionsANU Research Publications

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