Hogan, Simon; Rothenberg, Marc; Forbes, Elizabeth; Prescott, Vanessa; Matthaei, Klaus; Foster, Paul S
Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical...[Show more]
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