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Germline transcription of multiple TCR-V� genes in cloned T-cell lines

Abbey, Janice; O'Neill, Helen

Description

The functional significance of germline transcription of T cell receptor (TCR) beta chain variable (V) region genes is under investigation. The accepted model is that transcriptional activation of germline TCR genes is associated with the rearrangement process during T-cell development. By this model, germline expression of a subset of TCR- Vβ genes might be expected in early T cells which have not yet undergone rearrangement. Germline transcription of TCR- Vβ genes was analysed using the...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86264
Source: Immunology and Cell Biology
DOI: 10.1111/j.0818-9641.2004.01246.x

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