Dendritic Cell Development in Long-Term Spleen Stromal Cultures
O'Neill, Helen; Wilson, Heather; Quah, Ben; Abbey, Janice; Despars, Genevieve; Ni, Keping
Description
The cellular microenvironments in which dendritic cells (DCs) develop are not known. DCs are commonly expanded from CD34+ bone marrow precursors or blood monocytes using a cocktail of growth factors including GM-CSF. However, cytokine-supported cultures are not suitable for studying the intermediate stages of DC development, since progenitors are quickly driven to become mature DCs that undergo limited proliferation and survive for only a short period of time. This lab has developed a long-term...[Show more]
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/86263 |
Source: | Stem Cells |
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