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Retinal Colocalization and In Vitro Interaction of the Glutamate Receptor EAAT3 and the Serum- and Glucocorticoid-Inducible Kinase SGK1

Schniepp, Roman; Kohler, Konrad; Ladewig, Thomas; Guenther, Elke; Henke, Guido; Palmada, Monica; Boehmer, C; Rothstein, Jeffrey; Broer, Stefan; Lang, Florian

Description

PURPOSE. The serum- and glucocorticoid-inducible kinase SGK1 regulates several epithelial channels and transporters, the related protein kinase B (PKB) regulates glucose transport. SGK1 is expressed in the brain and could thus regulate glial and/or neuronal transport processes. The present study explores whether SGK1 is expressed in the retina and whether it regulates EAAT3, a Na+-coupled glutamate transporter. EAAT3 is expressed in retinal ganglion cells and accomplishes the clearance of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86260
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.03-0062

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