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Stimulation of the EAAT4 glutamate transporter by SGK protein kinase isoforms and PKB

Bohmer, Christoph; Philippin, Michaele; Rajamanickam, Jeyaganesh; Mack, A.F.; Broer, Stefan; Palmada, Monica; Lang, Florian

Description

The serum and glucocorticoid inducible kinase (SGK) 1 is expressed in brain tissue and upregulated by ischemia, neuronal excitation, and dehydration. The present study has been performed to elucidate the expression of SGK1 in cerebellar Purkinje cells and to explore whether it influences the colocalized glutamate transporter EAAT4. Intense SGK1 staining was observed in Purkinje cells following 48 h of water deprivation. The kinase activates glutamate induced current (IGLU) in Xenopus oocytes...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86257
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2004.09.193

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