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Exhaustion of Type I interferon response following an acute viral infection

Alsharifi, Mohammed; Regner, Matthias; Blanden, Robert; Lobigs, Mario; Lee, Eva; Koskinen, Aulikki; Mullbacher, Arno


Viral infections often cause a period of heightened susceptibility to a secondary infection but the cause of this phenomenon is unknown. We found that a primary viral infection in mice rapidly triggers an IFN-I-dependent partial activation state in the majority of B and T lymphocytes, which reverts to a resting phenotype within 5 days. When a secondary infection with an unrelated virus occurred 5 to 9 days after the primary infection, no recurrence of marked activation of lymphocytes was...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Immunology


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