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Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12

Mukherjee, Sutapa; Upham, John; Ramshaw, Ian; Bundell, Christine; van Bruggen, Ivonne; Robinson, Bruce; Nelson, Delia


Dendritic cell (DC) therapies using DC presenting tumor antigen/s can induce CD8+ CTL that mediate tumor eradication, nonetheless many patients remain unresponsive. Thus, cytokine gene vectors applied to DC may amplify these responses. Herein, we examined the responses that monocyte-derived DC (at different maturational stages) make when infected with a vaccinia virus-interleukin-2 (VV-IL-2) vector in vitro. VV-IL-2-infected DC secreted significant levels of bioactive IL-2 and maintained their...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Cancer Gene Therapy
DOI: 10.1038/sj.cgt.7700604


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