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CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis

Wang, Yang; Lobigs, Mario; Lee, Eva; Mullbacher, Arno


C57BL/6J mice infected intravenously with the Sarafend strain of West Nile virus (WNV) develop a characteristic central nervous system (CNS) disease, including an acute inflammatory reaction. Dose response studies indicate two distinct kinetics of mortality. At high doses of infection (108 PFU), direct infection of the brain occurred within 24 h, resulting in 100% mortality with a 6-day mean survival time (MST), and there was minimal destruction of neural tissue. A low dose (103 PFU) of...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.77.24.13323-13334.2003


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