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Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice

Leigh, Richard; Ellis, Russ; Wattie, Jennifer; Hirota, Jeremy; Matthaei, Klaus; Foster, Paul S; O'Byrne, Paul; Inman, Mark

Description

The mechanisms underlying airway hyperresponsiveness remain unclear, although airway inflammation and remodeling likely play important roles. We have observed sustained airway hyperreactivity and airway remodeling occurring in mice after chronic allergen

dc.contributor.authorLeigh, Richard
dc.contributor.authorEllis, Russ
dc.contributor.authorWattie, Jennifer
dc.contributor.authorHirota, Jeremy
dc.contributor.authorMatthaei, Klaus
dc.contributor.authorFoster, Paul S
dc.contributor.authorO'Byrne, Paul
dc.contributor.authorInman, Mark
dc.date.accessioned2015-12-13T23:07:00Z
dc.date.available2015-12-13T23:07:00Z
dc.identifier.issn1073-449X
dc.identifier.urihttp://hdl.handle.net/1885/86023
dc.description.abstractThe mechanisms underlying airway hyperresponsiveness remain unclear, although airway inflammation and remodeling likely play important roles. We have observed sustained airway hyperreactivity and airway remodeling occurring in mice after chronic allergen
dc.publisherAmerican Thoracic Society
dc.sourceAmerican Journal of Respiratory and Critical Care Medicine
dc.subjectKeywords: allergen; cytokine; interleukin 13; interleukin 4; interleukin 5; animal experiment; animal tissue; article; bronchus hyperreactivity; controlled study; cytokine production; female; histopathology; long term exposure; lung lavage; morphometrics; mouse; no Allergic disease; Asthma; Interleukin-13; Interleukin-4; Interleukin-5
dc.titleType 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume169
dc.date.issued2004
local.identifier.absfor110701 - Allergy
local.identifier.ariespublicationMigratedxPub14751
local.type.statusPublished Version
local.contributor.affiliationLeigh, Richard, McMaster University
local.contributor.affiliationEllis, Russ, McMaster University
local.contributor.affiliationWattie, Jennifer, McMaster University
local.contributor.affiliationHirota, Jeremy, McMaster University
local.contributor.affiliationMatthaei, Klaus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationO'Byrne, Paul, McMaster University
local.contributor.affiliationInman, Mark, McMaster University
local.bibliographicCitation.startpage860
local.bibliographicCitation.lastpage867
dc.date.updated2015-12-12T08:07:34Z
local.identifier.scopusID2-s2.0-1642529528
CollectionsANU Research Publications

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