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A New Fluorescence Resonance Energy Transfer Approach Demonstrates That the Histone Variant H2AZ Stabilizes the Histone octamer within the Nucleosome

Park, Young Ju; Dyer, Pamela; Tremethick, David; Luger, Karolin


Nucleosomes are highly dynamic macromolecular complexes that are assembled and disassembled in a modular fashion. One important way in which this dynamic process can be modulated is by the replacement of major histones with their variants, thereby affecting nucleosome structure and function. Here we use fluorescence resonance energy transfer between fluorophores attached to various defined locations within the nucleosome to dissect and compare the structural transitions of a H2A.Z containing...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M313152200


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