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Attenuation of conducted vasodilation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels

Goto, Kenichi; Rummery, Nicole; Grayson, Thomas; Hill, Caryl


The present study was designed to elucidate whether the conduction of vasomotor responses mediated by endothelium-derived hyperpolarizing factor (EDHF) in rat mesenteric arteries is altered during hypertension. Iontophoresed acetylcholine (ACh; 500 ms) caused EDHF-mediated hyperpolarization and vasodilatation at the local site and these responses spread through the endothelium to remote sites in 12-week-old Wistar-Kyoto rats (WKY). Conducted responses were significantly attenuated in...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2004.070458


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