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RNA interference demonstrates a novel role for H2A.Z in chromosome segregation

Rangasamy, Danny; Greaves, Ian; Tremethick, David


The histone variant H2A.Z plays an essential role in metazoans but its function remains to be determined. Here, we developed a new inducible RNAi strategy to elucidate the role of H2A.Z in mammalian cell lines. We show that in the absence of H2A.Z, the genome becomes highly unstable and that this instability is caused by defects in the chromosome segregation process. Analysis of H2A.Z localization reveals that in these cells it is enriched at heterochromatic foci with HP1α on the arms of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Nature Structural and Molecular Biology
DOI: 10.1038/nsmb786


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