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Unique Residues on the H2A.Z Containing Nucleosome Surface Are Important for Xenopus laevis Development

Ridgway, Patricia; Brown, Karl; Rangasamy, Danny; Svensson, Ulrica; Tremethick, David

Description

Critical to vertebrate development is a complex program of events that establishes specialized tissues and organs from a single fertilized cell. Transitions in chromatin architecture, through alterations in its composition and modification markings, characterize early development. A variant of the H2A core histone, H2A.Z, is essential for development of both Drosophila and mice. We recently showed that H2A.Z is required for proper chromosome segregation. Whether H2A.Z has additional specific...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86008
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M408409200

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