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Deubiquitinating Enzymes: Their Functions and Substrate Specificity

Soboleva, Tatiana; Baker, Rohan


Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the removal of ubiquitin, which is performed by deubiquitinating enzymes (DUBs). While it has been appreciated for some 10 years that DUBs constitute...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Current Protein and Peptide Science
DOI: 10.2174/1389203043379765


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