Fan, Jun; Rangasamy, Danny; Luger, Karolin; Tremethick, David
Controlling the degree of higher order chromatin folding is a key element in partitioning the metazoan genome into functionally distinct chromosomal domains. However, the mechanism of this fundamental process is poorly understood. Our recent studies suggested that the essential histone variant H2A.Z and the silencing protein HP1α may function together to establish a specialized conformation at constitutive heterochromatic domains. We demonstrate here that HP1α is a unique chromatin binding...[Show more]
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