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A role for eosinophils in airway remodelling in asthma

Kay, Adrian; Phipps, Simon; Robinson, Douglas

Description

Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of which is activated by epithelial-cell expression...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/85989
Source: Trends in Immunology
DOI: 10.1016/j.it.2004.07.006

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