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Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride

Premkumar, Anita; Wilson, L; Ewart, Gary; Gage, Peter

Description

A 63 residue peptide, p7, encoded by hepatitis C virus was synthesised and tested for ion channel activity in lipid bilayer membranes. Ion channels formed by p7 had a variable conductance: some channels had conductances as low as 14 pS. The reversal potential of currents flowing through the channels formed by p7 showed that they were permeable to potassium and sodium ions and less permeable to calcium ions. Addition of Ca2+ to solutions made channels formed by p7 less potassium- or...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/85973
Source: FEBS Letters
DOI: 10.1016/S0014-5793(03)01453-4

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