Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages
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Ewart, Gary; Nasr, Najla; Naif, Hassan; Cox, Graeme; Cunningham, Anthony; Gage, Peter
Description
We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/85972 |
Source: | Antimicrobial Agents and Chemotherapy |
DOI: | 10.1128/AAC.48.6.2325-2330.2004 |
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