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An Amino-Acid Substitution in the Influenza-B NB Protein Affects Ion-Channel Gating

Premkumar, Anita; Ewart, Gary; Cox, Graeme; Gage, Peter


The effects of site-directed mutations in NB, a protein encoded by the influenza B virus that has been shown to form cation-selective ion channels at pH 6.0, were studied on ion channel characteristics in artificial lipid bilayers. It was thought that the residues in the hydrophobic region of NB we selected for mutation might be involved in the transport of cations across the channel and that changes in these residues might affect channel properties such as gating and ion-selectivity. Serine...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s00232-004-0648-0


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