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Nitric oxide contributes to resistance of the Brown Norway Rat to experimental autoimmune encephalomyelitis

Staykova, Maria; Paridaen, Judith T; Cowden, William; Willenborg, David


The Brown Norway (BN) rat is reported to be resistant to the induction of experimental autoimmune encephalomyelitis (EAE) and a number of mechanisms have been suggested to explain this resistance. In work reported here we provide evidence that such resistance in the BN rat can be accounted for, at least in part, by their ability to produce higher levels of nitric oxide (NO) than susceptible strains of rats. Spleen cells from the BN rat make significantly more NO following in vitro stimulation...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: American Journal of Pathology


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