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A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis

Levidiotis, Vicki; Freeman, Craig; Punler, Malcolm; Martinello, Paul; Creese, Brian; Ferro, Vito; van der Vlag, Johan; Berden, Jo; Power, David A; Parish, Christopher


The β-D-endoglycosidase heparanase has been proposed to be important in the pathogenesis of proteinuria by acting to selectively degrade the negatively charged side chains of heparan sulfate proteoglycans (HSPG) within the glomerular basement membrane (G

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of the American Society of Nephrology
DOI: 10.1097/01.ASN.0000142426.55612.6D


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