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Total synthesis of the marine alkaloid halitulin

Heinrich, Markus; Steglich, Wolfgang; Banwell, Martin; Kashman, Yoel


The structure of the strongly cytotoxic marine alkaloid halitulin (1) has been confirmed by total synthesis and its absolute configuration determined as (15S). The synthesis follows a strategy previously reported by one of us and uses an efficient preparation of the quinoline-7,8-diol unit by modified Baeyer-Villiger and Skraup reactions. The O-benzyl protecting groups were removed in the last step of the synthesis by transfer hydrogenolysis without concomitant reduction of the quinoline ring....[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Tetrahedron
DOI: 10.1016/j.tet.2003.02.005


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