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Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros Transcription Factor

Papathanasiou, Panagiotis; Perkins, Andrew C; Cobb, Bradley S; Ferrini, Roger; Sridharan, Rupa; Hoyne, Gerard; Nelms, Keats; Smale, Stephen T; Goodnow, Christopher

Description

A central issue in understanding the hematolymphoid system is the generation of appropriate mutant alleles in mice to reveal the function of regulatory genes. Here we describe a mouse strain, Plastic, with a point mutation in a zinc finger of Ikaros that

dc.contributor.authorPapathanasiou, Panagiotis
dc.contributor.authorPerkins, Andrew C
dc.contributor.authorCobb, Bradley S
dc.contributor.authorFerrini, Roger
dc.contributor.authorSridharan, Rupa
dc.contributor.authorHoyne, Gerard
dc.contributor.authorNelms, Keats
dc.contributor.authorSmale, Stephen T
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T23:06:05Z
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/1885/85855
dc.description.abstractA central issue in understanding the hematolymphoid system is the generation of appropriate mutant alleles in mice to reveal the function of regulatory genes. Here we describe a mouse strain, Plastic, with a point mutation in a zinc finger of Ikaros that
dc.publisherCell Press
dc.sourceImmunity
dc.subjectKeywords: DNA; Ikaros transcription factor; transcription factor; unclassified drug; allele; animal cell; animal experiment; animal tissue; article; cell differentiation; cell maturation; complex formation; controlled study; DNA binding; embryo; embryo development;
dc.titleWidespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros Transcription Factor
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume19
dc.date.issued2003
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub14526
local.type.statusPublished Version
local.contributor.affiliationPapathanasiou, Panagiotis, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPerkins, Andrew C, Monash University
local.contributor.affiliationCobb, Bradley S, University of California
local.contributor.affiliationFerrini, Roger, University of California
local.contributor.affiliationSridharan, Rupa, University of California
local.contributor.affiliationHoyne, Gerard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationNelms, Keats, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSmale, Stephen T, University of California
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage131
local.bibliographicCitation.lastpage144
local.identifier.doi10.1016/S1074-7613(03)00168-7
dc.date.updated2015-12-12T08:03:35Z
local.identifier.scopusID2-s2.0-0038106526
CollectionsANU Research Publications

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