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Carbohydrate-protein conjugate vaccines

Ada, Gordon; Isaacs, D


Various pathogenic bacteria have coats of polysaccharide, many with repeating epitopes. Though polysaccharide vaccines have been available for some time, they induce mainly IgM production, and are only moderately protective in adults and ineffective in young children. It was originally shown in 1931 that the immunogenicity of polysaccharides could be enhanced by conjugating to a protein. The last two decades have witnessed the production and clinical testing of polysaccharide-protein conjugates...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Clinical Microbiology and Infection
DOI: 10.1046/j.1469-0691.2003.00530.x


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