The Intramolecular Carboxyarylation Approach to Podophyllotoxin
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Reynolds, Aaron; Scott, Andrew; Turner, Craig; Sherburn, Michael
Description
Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial production. Two are semisynthetic derivatives of podophyllotoxin. This paper describes concise, highly convergent, and conceptually novel approaches to (-)-podophyllotoxin and its enantiomer. These highly convergent syntheses feature a late-stage domino radical reaction to install the lactone ring and the pendant trimethoxyphenyl group.
Collections | ANU Research Publications |
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Date published: | 2003 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/85847 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/ja0376588 |
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01_Reynolds_The_Intramolecular_2003.pdf | 73.73 kB | Adobe PDF | Request a copy |
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