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The Intramolecular Carboxyarylation Approach to Podophyllotoxin

Reynolds, Aaron; Scott, Andrew; Turner, Craig; Sherburn, Michael


Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial production. Two are semisynthetic derivatives of podophyllotoxin. This paper describes concise, highly convergent, and conceptually novel approaches to (-)-podophyllotoxin and its enantiomer. These highly convergent syntheses feature a late-stage domino radical reaction to install the lactone ring and the pendant trimethoxyphenyl group.

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja0376588


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