Evidence that a mechanism for efficient flavivirus budding upregulates MHC class 1
An appealing hypothesis for the biological role of flavivirus-induced, interferon-independent, upregulation of MHC class I on the surface of infected cells is that of viral immune evasion from NK cell recognition. Here we show that a mechanism for efficient flavivirus morphogenesis interferes with the MHC class I pathway, using a flavivirus budding mutant and recombinant expression of wild-type and mutant forms of the flavivirus structural proteins. We propose that the phenomenon of...[Show more]
|Collections||ANU Research Publications|
|Source:||Immunology and Cell Biology|
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