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Micromanipulation of phospholipid bilayers by atomic force microscopy

Maeda, Nobuo; Senden, Timothy; Di Meglio, Jean-Marc


The molecular details of adhesion mechanics in phospholipid bilayers have been studied using atomic force microscopy (AFM). Under tension fused bilayers of dipalmitoylphosphatidylcholine (DPPC) yield to give non-distance dependent and discrete force plateaux of 45.4, 81.6 and 113±3.5 pN. This behaviour may persist over distances as great as 400 nm and suggests the stable formation of a cylindrical tube which bridges the bilayers on the two surfaces. The stability of this connective structure...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Biochimica et Biophysica Acta: Biomembranes
DOI: 10.1016/S0005-2736(02)00443-1


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