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Use of γ-inulin/liposomes/Vitamin E adjuvant combination in contraceptive vaccines

Fuentes, P; Cooper, Peter; Barnadas, R; Sabes, M; Osterhoff, C; Martinez, P


The adjuvanticity of two gamma inulin/liposomes/Vitamin E combinations was evaluated in the mouse, in contraceptive vaccines with sperm protein extracts or a synthetic HE2 peptide ("Human Epididymis gene product"; residues 15-28) as antigen. The HE2 peptide was not conjugated to a protein carrier, to ensure that the antibodies elicited were specific against the HE2 peptide. The adjuvant combinations were designed to increase adjuvanticity, as their components have complementary mechanisms, and...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: International Journal of Pharmaceutics
DOI: 10.1016/S0378-5173(03)00127-3


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