Ranson, Hilary; Claudianos, Charles; Ortelli, Frederika; Abgrall, Christelle; Hemingway, Janet; Sharakhova, Maria; Unger, Maria; Collins, Frank H; Feyereisen, R
The emergence of insecticide resistance in the mosquito poses a serious threat to the efficacy of many malaria control programs. We have searched the Anopheles gambiae genome for members of the three major enzyme families - the carboxylesterases, glutathione transferases, and cytochrome P450s - that are primarily responsible for metabolic resistance to insecticides. A comparative genomic analysis with Drosophila melanogaster reveals that a considerable expansion of these supergene families has...[Show more]
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