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Evolution of supergene families associated with insect resistance

Ranson, Hilary; Claudianos, Charles; Ortelli, Frederika; Abgrall, Christelle; Hemingway, Janet; Sharakhova, Maria; Unger, Maria; Collins, Frank H; Feyereisen, R


The emergence of insecticide resistance in the mosquito poses a serious threat to the efficacy of many malaria control programs. We have searched the Anopheles gambiae genome for members of the three major enzyme families - the carboxylesterases, glutathione transferases, and cytochrome P450s - that are primarily responsible for metabolic resistance to insecticides. A comparative genomic analysis with Drosophila melanogaster reveals that a considerable expansion of these supergene families has...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Science
DOI: 10.1126/science.1076781


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