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Buprenorphine dosing regime in the management of out-patient heroin withdrawal

Lintzeris, Nicholas

Description

This study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutexr tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were...[Show more]

dc.contributor.authorLintzeris, Nicholas
dc.date.accessioned2015-12-13T23:05:46Z
dc.identifier.issn0959-5236
dc.identifier.urihttp://hdl.handle.net/1885/85695
dc.description.abstractThis study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutexr tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were 6.1 (1.2) mg on day 1; 9.6 (1.7) mg on day 2; 10.1 (1.9) mg on day 3; 8.9 (2.0) mg on day 4; 4.1 (1.5) mg on day 5; and a total regime dose of 38. 9 (5. 8) mg. Withdrawal severity was mild, with minimal rebound upon the cessation of dosing. Five subjects reported no heroin use, and five subjects reported using on only one occasion during the 8 days. An out-patient buprenorphine regime is recommended.
dc.publisherCarfax Publishing, Taylor & Francis Group
dc.sourceDrug and Alcohol Review
dc.subjectKeywords: buprenorphine; adult; ambulatory care; article; drug administration; female; heroin dependence; hospitalization; human; male; methodology; patient satisfaction; psychological aspect; statistics; withdrawal syndrome; Adult; Ambulatory Care; Buprenorphine; Buprenorphine; Detoxification; Dose regimes; Heroin withdrawal
dc.titleBuprenorphine dosing regime in the management of out-patient heroin withdrawal
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume21
dc.date.issued2002
local.identifier.absfor111799 - Public Health and Health Services not elsewhere classified
local.identifier.ariespublicationMigratedxPub14285
local.type.statusPublished Version
local.contributor.affiliationLintzeris, Nicholas, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage39
local.bibliographicCitation.lastpage45
local.identifier.doi10.1080/09595230220119309
dc.date.updated2015-12-12T08:02:11Z
local.identifier.scopusID2-s2.0-0036004062
CollectionsANU Research Publications

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