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The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

Hirst, C E; Buzza, Marguerite; Bird, Catherina; Warren, Hilary; Cameron, P B; Zhang, Manling; Ashton-Rickardt, Philip G; Bird, Phillip I


Granzyme B (grB) is a serine proteinase released by cytotoxic lymphocytes (CLs) to kill abnormal cells. GrB-mediated apoptotic pathways are conserved in nucleated cells; hence, CLs require mechanisms to protect against ectopic or misdirected grB. The nucleocytoplasmic serpin, proteinase inhibitor 9 (PI-9), is a potent inhibitor of grB that protects cells from grB-mediated apoptosis in model systems. Here we show that PI-9 is present in CD4+ cells, CD8+ T cells, NK cells, and at lower levels in...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Immunology


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