Skip navigation
Skip navigation

Inhibition of Nuclear Import Mediated by the Rev-Arginine Rich Motif by RNA Molecules

Fineberg, Konstantin; Fineberg, Tali; Graessmann, Adolf; Luedtke, Nathan; Tor, Yitzhak; Rui, Lixin; Jans, David A; Loyter, Abraham

Description

The HIV-1 Rev protein plays a pivotal role in viral replication, and therefore, inhibition of its function should block the progression of the virus-induced immune deficiency syndrome (AIDS). Here, RNA molecules have been shown to inhibit import of the HIV-1 Rev protein into nuclei of permeabilized cells. Nuclear uptake of biotinylated recombinant His-tagged Rev-GFP was assessed in nuclear extracts from digitonin-permeabilized cells by binding to either importin β-receptors or nickel molecules...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/85672
Source: Biochemistry
DOI: 10.1021/bi0206199

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator