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CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels

Board, Philip; Coggan, Marjorie; Watson, Sarah; Gage, Peter; Dulhunty, Angela


We have examined the biochemical and functional properties of the recently identified, uncharacterised CLIC-2 protein. Sequence alignments showed that CLIC-2 has a high degree of sequence similarity with CLIC-1 and some similarity to the omega class of glutathione transferases (GSTO). A homology model of CLIC-2 based on the crystal structure of CLIC-1 suggests that CLIC-2 belongs to the GST structural family but, unlike the GSTs, CLIC-2 exists as a monomer. It also has an unusual enzyme...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2004.01.026


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