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Glutathione Transferase Zeta-Catalyzed Bioactivation of Dichloroacetic Acid: Reaction of Glyoxylate with Amino Acid Nucleophiles

Anderson, Wayne; Board, Philip; Anders, Michael

Description

Dichloroacetic acid (DCA) is a drinking water contaminant, a therapeutic agent, and a rodent carcinogen. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of α-haloalkanoates and the cis-trans isomerization of maleylacetoa

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/85471
Source: Chemical Research in Toxicology
DOI: 10.1021/tx034099+

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