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Multiple Actions of Imperatoxin A on Ryanodine Receptors - Interactions with the II-III Loop A Fragment*

Dulhunty, Angela; Curtis, Suzanne; Watson, Sarah; Cengia, Louise; Casarotto, Marco

Description

Imperatoxin A is a high affinity activator of ryanodine receptors. The toxin contains a positively charged surface structure similar to that of the A fragment of skeletal dihydropyridine receptors (peptide A), suggesting that the toxin and peptide could bind to a common site on the ryanodine receptor. However, the question of a common binding site has not been resolved, and the concentration dependence of the actions of the toxin has not been fully explored. We characterize two novel high...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/85447
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M310466200

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