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Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release

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Dulhunty, Angela; Curtis, Suzanne; Cengia, Louise; Sakowska, Magdalena; Casarotto, Marco

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We show that peptide fragments of the dihydropyridine receptor II-III loop alter cardiac RyR (ryanodine receptor) channel activity in a cytoplasmic Ca 2+-dependent manner. The peptides were Ac (Thr-793-Ala-812 of the cardiac dihydropyridine receptor), As

dc.contributor.authorDulhunty, Angela
dc.contributor.authorCurtis, Suzanne
dc.contributor.authorCengia, Louise
dc.contributor.authorSakowska, Magdalena
dc.contributor.authorCasarotto, Marco
dc.date.accessioned2015-12-13T23:05:16Z
dc.identifier.issn0264-6021
dc.identifier.urihttp://hdl.handle.net/1885/85446
dc.description.abstractWe show that peptide fragments of the dihydropyridine receptor II-III loop alter cardiac RyR (ryanodine receptor) channel activity in a cytoplasmic Ca 2+-dependent manner. The peptides were Ac (Thr-793-Ala-812 of the cardiac dihydropyridine receptor), As
dc.publisherPortland Press
dc.sourceBiochemical Journal
dc.subjectKeywords: Biochemistry; Cytology; Lipids; Nuclear magnetic resonance; Plasmas; Cytoplasmic; Helical; Peptide fragments; Sarcoplasmic; Cardiology; 1,4 dihydropyridine receptor; alanine; heart receptor; ion channel; leucine; peptide fragment; protein subunit; threoni Cardiac ryanodine receptor activity; Dihydropyridine receptor; Muscle contraction; Ryanodine receptor probe
dc.titlePeptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume379
dc.date.issued2004
local.identifier.absfor110106 - Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
local.identifier.ariespublicationMigratedxPub13854
local.type.statusPublished Version
local.contributor.affiliationDulhunty, Angela, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCurtis, Suzanne, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCengia, Louise, Biotron Ltd
local.contributor.affiliationSakowska, Magdalena, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCasarotto, Marco, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage161
local.bibliographicCitation.lastpage172
local.identifier.doi10.1042/BJ20031096
dc.date.updated2015-12-12T07:59:28Z
local.identifier.scopusID2-s2.0-1842844287
CollectionsANU Research Publications

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