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ACTIVATING THE RYANODINE RECEPTOR WITH DIHYDROPYRIDINE RECEPTOR II-III LOOP SEGMENTS: SIZE AND CHARGE DO MATTER

Casarotto, Marco; Green, Daniel; Pace, Suzy M; Young, Jaqui; Dulhunty, Angela

Description

Excitation-contraction coupling in skeletal muscle is thought to depend on a physical interaction between II-III loop of the alpha1 subunit of the skeletal dihydropyridine receptor (DHPR) and ryanodine receptor (RyR). A peptide corresponding to II-III loop residues 671-690 of the skeletal DHPR (peptide A) is a high affinity activator of the RyR when it adopts an alpha-helical structure with critical basic residues aligned along one helical surface (1). Neither the structure of the full length...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/85441
Source: Frontiers in Bioscience
DOI: 10.2741/1443

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