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Heritable and inducible gene knockdown in C. elegans using Wormgate and the ORFeome

Johnson, Nick; Behm, Carolyn; Trowell, Stephen Charles


Double-stranded RNA (dsRNA) mediated gene silencing (RNA interference; RNAi) is a powerful tool for investigating gene function. It is usually performed in Caenorhabditis elegans via the injection or oral delivery of dsRNA, but an alternative approach, the expression of RNA hairpins from introduced DNA (hairpin RNAi; hpRNAi) has several advantages: (1) it can be induced systemically or in a tissue-specific manner; (2) because it is heritable, it allows consistent RNAi silencing across a whole...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Gene
DOI: 10.1016/j.gene.2005.05.034


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