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Bayesian designs with frequentist and Bayesian error rate considerations

Wang, You-Gan; Leung, Denis Heng-Yan; Li, Manning; Tan, Say-Beng

Description

So far, most Phase II trials have been designed and analysed under a frequentist framework. Under this framework, a trial is designed so that the overall Type I and Type II errors of the trial are controlled at some desired levels. Recently, a number of articles have advocated the use of Bayesian designs in practice. Under a Bayesian framework, a trial is designed so that the trial stops when the posterior probability of treatment is within certain prespecified thresholds. In this article, we...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/85389
Source: Statistical Methods in Medical Research
DOI: 10.1191/0962280205sm410oa

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