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Magnetic resonance imaging study in older fragile X premutation male carriers

Loesch, Danuta Z; Litewka, Lucas; Brotchie, Peter; Huggins, Richard; Tassone, Flora; Cook, Mark


Some carriers of a "premutation" allele of the FMR1 gene develop late-onset tremor/ataxia. We conducted a magnetic resonance imaging volumetric study in an unselected sample of eight older male premutation carriers. Volumetric measures, including total brain volume, and the volumes of cerebrum, cerebellum, and cerebral cortex all were significantly reduced in premutation carriers compared with similar data from 21 age-matched normal controls. Total brain and cerebral volumes were significantly...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Annals of Neurology
DOI: 10.1002/ana.20542


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