Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1
Downie, Megan; Saliba, Kevin; Howitt, Susan; Broer, Stefan; Kirk, Kiaran
Like all parasitic protozoa, the human malaria parasite Plasmodium falciparum lacks the enzymes required for de novo synthesis of purines and it is therefore reliant upon the salvage of these compounds from the external environment. P. falciparum equilibrative nucleoside transporter 1 (PfENT1) is a nucleoside transporter that has been localized to the plasma membrane of the intraerythrocytic form of the parasite. In this study we have characterized the transport of purine and pyrimidine...[Show more]
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