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A/T-targeted somatic hypermutation: critique of the mainstream model

Blanden, Robert; Franklin, Andrew

Description

The 'affinity maturation' of the humoral immune response is driven by antigen-activated somatic hypermutation (SHM) of the genes that encode antibody variable regions and the subsequent antigenic selection of mutant clones. The molecular mechanism of SHM

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/85272
Source: Trends in Biochemical Sciences
DOI: 10.1017/S1047951106000321

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