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Adjusting data to body size: A comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes

Lang, Dean H; Sharkey, Neil A; Lionikas, Arimantas; Mack, Holly; Larsson, Lars; Vogler, George P; Vandenbergh, David J; Blizard, David A; Stout, Joseph T; Stitt, Joseph P; McClearn, Gerald E


The aim of this study was to compare three methods of adjusting skeletal data for body size and examine their use in QTL analyses. It was found that dividing skeletal phenotypes by body mass index induced erroneous QTL results. The preferred method of body size adjustment was multiple regression. Introduction: Many skeletal studies have reported strong correlations between phenotypes for muscle, bone, and body size, and these correlations add to the difficulty in identifying genetic influence...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Bone and Mineral Research
DOI: 10.1359/JBMR.041224


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